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McKesson Corp
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Bio X Cell
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ASTRUM IT GmbH
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Galectin Therapeutics
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Bio X Cell
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Bruker Corporation
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Bio X Cell
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Image Search Results
Journal: Cancers
Article Title: Promises of Protein Kinase Inhibitors in Recalcitrant Small-Cell Lung Cancer: Recent Scenario and Future Possibilities
doi: 10.3390/cancers16050963
Figure Lengend Snippet: Immune checkpoint (IC) blockade and related clinical trials in SCLC. PD-L1 expressed on cancer cells interacts with PD-1 on T cells to activate exhaustion and suppression pathways in T cells. Immune checkpoint inhibitors (ICIs) that impede this interaction have been developed and evaluated in different clinical trials for treatment-naïve ES-SCLC, combined with standard-of-care chemotherapy. The clinical trials include IMpower133 evaluating Atezolizumab (anti-PD-L1 antibody), CASPIAN evaluating Durvalumab (anti-PD-L1 antibody), Keynote-604 evaluating Pembrolizumab (anti-PD-1 antibody), CAPSTONE-1 evaluating Adebrelimab (anti-PD-L1 antibody) and ASTRUM-005 evaluating Serplulimab (anti-PD-1 antibody). [Created with BioRender.com (accessed on 18 February 2024)].
Article Snippet: 5 , NCT04063163 (
Techniques: Clinical Proteomics
Journal: Cancers
Article Title: Promises of Protein Kinase Inhibitors in Recalcitrant Small-Cell Lung Cancer: Recent Scenario and Future Possibilities
doi: 10.3390/cancers16050963
Figure Lengend Snippet: List of clinical trials in phase III for treatment-naïve ES-SCLC patients.
Article Snippet: 5 , NCT04063163 (
Techniques: Clinical Proteomics, Control